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KMID : 0378019610040030117
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New Medical Journal
1961 Volume.4 No. 3 p.117 ~ p.121
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Protective Effect of KCI on Acute NaCl Intoxication
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Abstract
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Three kinds of hypertonic solution which are identical in osmolarity(3000mOsm.) and in anionic composition(Cl, HCO3) but differing only in their cationic oncentrations(Na and 1") were administered intraperitoneally to rats.
The 36 animals were devided into three major groups of 12 animals each. In each group 6 rats received 3.0 ml. per 100 gm body weight of the hypertonic solution being studied and 6 received 2.0 ml. per 100 grn body weight of that solution. Observations were made for 24 hours after the administration when they were sacrificed, if not already dead, to ascertain the presence of intracraniai hemorrhage.
The solution which contained 1500mEq/L of sodium and no potassium induced marked cerebral symptoms such as convulsions and coma with marked to moderate degree of iatracranial bleeding regardless of volume administered.
The solution which contained IOOmEq /L of potassium and 1400mEq /L of sodium induced moderate cerebral symptoms and also moderate intracramial hemorrhage to rats administered 3.0ml. per 100gm body weight. However, rats given 2.Oml per 100gm body weight induced milder cerebral symptoms and also milder intracranial hemorrhage.
The solution which contained 500m1:q/L of potassium and 10OOmEq/L of sodium brought rapid death (within 20 minutes after injection) to rats administered 3.0m1. per 100gm body weight, without any evidence of intracranial hemorrhage. It is suggested that the addition of potassium had protective effect on the symptoms of hypernatremia which had been induced by the injection of large amount of sodium chloride.
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